ID   BIONi010C-48
AC   CVCL_D6PB
SY   BIONi010-C hMDR1; BIONi010-C CAG_hMDR1 in AAVS1 cl. #B31-75
DR   BioSamples; SAMEA115286272
DR   hPSCreg; BIONi010-C-48
RX   PubMed=38364505;
CC   From: Bioneer A/S; Horsholm; Denmark.
CC   Population: African.
CC   Characteristics: Using TALEN a ABCB1/MDR1-neo construct was introduced in both alleles of the AAVS1 safe harbor locus (PubMed=38364505).
CC   Genetic integration: Method=TALEN; Gene=HGNC; 40; ABCB1.
CC   Genetic integration: Method=TALEN; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1E68 ! BIONi010-C
SX   Male
AG   18Y
CA   Induced pluripotent stem cell
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=38364505; DOI=10.1016/j.scr.2024.103348;
RA   Nielsen A.K.R., Lilieholm-Rongren L., Schmid B., Holst B., Brodin B.,
RA   Saaby L.;
RT   "Generation of an iPSC-line (BIONi010C-48) with restored
RT   P-glycoprotein functionality following transfection with the human
RT   MDR1 gene in the AAVS1 locus.";
RL   Stem Cell Res. 76:103348-103348(2024).
//