Cellosaurus cell line HyCyte PANC-1 KO-hFBXW7 (CVCL

Cross-references
Cell line name	HyCyte PANC-1 KO-hFBXW7
Synonyms	hFBXW7 knockout PANC-1
Accession	CVCL_D6CA
Resource Identification Initiative	To cite this cell line use: HyCyte PANC-1 KO-hFBXW7 (RRID:CVCL_D6CA)
Comments	Population: Caucasian. Doubling time: 48-72 hours (Hysigen=CGKO-M2348). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:16712; FBXW7. Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0480 (PANC-1)
Sex of cell	Male
Age at sampling	56Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2348
Encyclopedic resources	Wikidata; Q127382047
Entry history
Entry creation	02-May-2024
Last entry update	19-Dec-2024
Version number	3