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Cellosaurus MCF-7:WS8 (CVCL_D5YA)

[Text version]
Cell line name MCF-7:WS8
Accession CVCL_D5YA
Resource Identification Initiative To cite this cell line use: MCF-7:WS8 (RRID:CVCL_D5YA)
Comments Population: Caucasian.
Characteristics: Highly sensitive to estrogen-stimulated growth.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_D5YB (MCF-7 1403)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8600466; DOI=10.1093/nar/24.5.962; PMCID=PMC145723
Pink J.J., Wu S.-Q., Wolf D.M., Bilimoria M.M., Jordan V.C.
A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7.
Nucleic Acids Res. 24:962-969(1996)

PubMed=15862958; DOI=10.1016/j.jsbmb.2004.12.032
Lewis-Lambi J.S., Osipo C., Meeke K., Jordan V.C.
Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal.
J. Steroid Biochem. Mol. Biol. 94:131-141(2005)

PubMed=24604139; DOI=10.3892/ijo.2014.2329; PMCID=PMC4144033
Sweeney E.E., Fan P., Jordan V.C.
Mechanisms underlying differential response to estrogen-induced apoptosis in long-term estrogen-deprived breast cancer cells.
Int. J. Oncol. 44:1529-1538(2014)

Cross-references
Encyclopedic resources Wikidata; Q127382749
Entry history
Entry creation02-May-2024
Last entry update10-Sep-2024
Version number2