Cellosaurus cell line NPC268 (CVCL

Cellosaurus NPC268 (CVCL_D5KT)

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Cell line name

NPC268

Accession

CVCL_D5KT

Resource Identification Initiative

To cite this cell line use: NPC268 (RRID:CVCL_D5KT)

Comments

Population: Chinese; Malaysian.
Doubling time: ~4.5 days (PubMed=38358347).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pharynx, nasopharynx; UBERON=UBERON_0001728.
Cell type: Epithelial cell; CL=CL_0000066.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=38358347).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=38358347).
Gene deletion; HGNC; HGNC:7413; MTAP; Zygosity=Homozygous (PubMed=38358347).
Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Heterozygous (PubMed=38358347).
Mutation; HGNC; HGNC:1541; CBL; Simple; p.Asp772Glu (c.2316T>G); ClinVar=VCV000477707; Zygosity=Heterozygous (PubMed=38358347).
Mutation; HGNC; HGNC:1748; CDH1; Simple; p.Arg124His (c.371G>A); ClinVar=VCV000141538; Zygosity=Heterozygous (PubMed=38358347).
Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Asp7Gly (c.20A>G); ClinVar=VCV001251597; Zygosity=Homozygous (PubMed=38358347).
Mutation; HGNC; HGNC:9122; PMS2; Simple; p.Leu47Val (c.139C>G); ClinVar=VCV000219785; Zygosity=Heterozygous (PubMed=38358347).

Disease

Nasopharyngeal differentiated carcinoma (NCIt: C54389)
Nasopharyngeal carcinoma (ORDO: Orphanet_150)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

39Y

Category

Cancer cell line

STR profile

Source(s): PubMed=38358347

Markers:

Amelogenin	X
CSF1PO	9,13
D1S1656	14,16
D2S441	11,14
D2S1338	23,24
D3S1358	16
D5S818	12,13
D7S820	11,12
D8S1179	15
D10S1248	13,16
D12S391	21,24
D13S317	8,9
D16S539	11,13
D18S51	15
D19S433	14.2,16.2
D21S11	30,32.2
D22S1045	15,17
FGA	24
Penta D	8,9
Penta E	11,13
TH01	7,8
TPOX	8
vWA	14,17

Publications

PubMed=38358347; DOI=10.1158/2767-9764.CRC-23-0341; PMCID=PMC10911800
Annie Wai-Yeeng Chai, Shi-Mun Yee, Hui-Mei Lee, Norazlin Abdul Aziz, Pei-San Yee, Marini Marzuki, Ka-Wo Wong, Alan Kwok-Shing Chiang, Larry Ka-Yue Chow, Wei Dai, Teng-Fei Liu ...Show all 20 authors... , Lu-Ping Tan, Alan Soo-Beng Khoo, Kwok-Wai Lo, Paul V.-H. Lim, Pathmanathan Rajadurai, Howard Lightfoot, Syd Barthorpe, Mathew J. Garnett, Sok-Ching Cheong; Show fewer authors
Establishment and characterization of an Epstein-Barr virus-positive cell line from a non-keratinizing differentiated primary nasopharyngeal carcinoma.
Cancer Res. Commun. 4:645-659(2024)

Cross-references

Cell line databases/resources

Cell_Model_Passport; SIDM01990

Encyclopedic resources

Wikidata; Q127382967

Gene expression databases

GEO; GSE233426

Sequence databases

EGA; EGAS00001007172

Entry history

Entry creation

02-May-2024

Last entry update

10-Apr-2025

Version number