ID   MKN45cl85
AC   CVCL_D5HU
DR   GEO; GSM3097051
DR   GEO; GSM3097052
DR   GEO; GSM3097053
DR   Wikidata; Q127382830
RX   PubMed=23659450;
RX   PubMed=30410674;
CC   Population: Japanese.
CC   Characteristics: Parent cell line was injected subcutaneously in BALB/c nude mice. Cachexia-inducing tumor cells were harvested and re-injected into mice. This process was carried out 10 times (PubMed=23659450).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0434 ! MKN45
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 02-05-24; Last updated: 10-09-24; Version: 2
//
RX   PubMed=23659450; DOI=10.1080/01635581.2013.776089;
RA   Yanagihara K., Takigahira M., Mihara K., Kubo T., Morimoto C.,
RA   Morita Y., Terawaki K., Uezono Y., Seyama T.;
RT   "Inhibitory effects of isoflavones on tumor growth and cachexia in
RT   newly established cachectic mouse models carrying human stomach
RT   cancers.";
RL   Nutr. Cancer 65:578-589(2013).
//
RX   PubMed=30410674; DOI=10.18632/oncotarget.26190; PMCID=PMC6205166;
RA   Terawaki K., Kashiwase Y., Uzu M., Nonaka M., Sawada Y., Miyano K.,
RA   Higami Y., Yanagihara K., Yamamoto M., Uezono Y.;
RT   "Leukemia inhibitory factor via the Toll-like receptor 5 signaling
RT   pathway involves aggravation of cachexia induced by human gastric
RT   cancer-derived 85As2 cells in rats.";
RL   Oncotarget 9:34748-34764(2018).
//