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Cellosaurus RWLeu-4 (CVCL_D591)

[Text version]
Cell line name RWLeu-4
Synonyms RWLEU-4; RWLeu 4; RWLeu4; Roger Williams Leukemia-4
Accession CVCL_D591
Resource Identification Initiative To cite this cell line use: RWLeu-4 (RRID:CVCL_D591)
Comments Characteristics: Proliferation inhibited by vitamin D3 (PubMed=1372318; PubMed=7994044).
Doubling time: 33 hours (CelloPub=CLPUB00106); 25-26 hours (PubMed=2159372).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D592 (JMRD3)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

CLPUB00106
Wiemann M.C., Hollmann A., Posner M.R.
Establishment of a new Philadelphia chromosome-positive human chronic myeloid leukemia cell line.
Clin. Res. 33:460A-460A(1985)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=2159372
Lasky S.R., Bell W., Huhn R.D., Posner M.R., Wiemann M.C., Calabresi P., Eil C.
Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4.
Cancer Res. 50:3087-3094(1990)

PubMed=1372318; DOI=10.1007/BF01410133
Clark J.W., Posner M.R., Marsella J.M., Santos A., Uskokovic M.R., Eil C., Lasky S.R.
Effects of analogs of 1,25(OH)2 vitamin D3 on the proliferation and differentiation of the human chronic myelogenous leukemia cell line, RWLeu-4.
J. Cancer Res. Clin. Oncol. 118:190-194(1992)

PubMed=7994044; DOI=10.1182/blood.V84.12.4283.bloodjournal84124283
Lasky S.R., Posner M.R., Iwata K., Santos-Moore A., Yen A., Samuel V., Clark J.W., Maizel A.L.
Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line.
Blood 84:4283-4294(1994)

PubMed=8635507; DOI=10.1006/excr.1996.0165
Iwata K., Kouttab N., Ogata H., Morgan J.W., Maizel A.L., Lasky S.R.
Differential regulation of vitamin D receptors in clonal populations of a chronic myelogenous leukemia cell line.
Exp. Cell Res. 225:143-150(1996)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

Cross-references
Anatomy/cell type resources BTO; BTO_0005332
Chemistry resources ChEMBL-Cells; CHEMBL3307431
ChEMBL-Targets; CHEMBL614885
PubChem_Cell_line; CVCL_D591
Encyclopedic resources Wikidata; Q54951494
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number21