ID   Mel-RM
AC   CVCL_D548
SY   Mel RM
DR   BTO; BTO:0005715
DR   EFO; EFO_0022452
DR   cancercelllines; CVCL_D548
DR   Cosmic; 889010
DR   Wikidata; Q54905129
RX   PubMed=7520026;
RX   PubMed=8980186;
RX   PubMed=9725211;
RX   PubMed=10364001;
RX   PubMed=15048078;
RX   PubMed=22383533;
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; None_reported; -; Zygosity=- (PubMed=15048078).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (PubMed=22383533).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-09-24; Version: 16
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RX   PubMed=7520026; DOI=10.1002/ijc.2910580413;
RA   Hersey P., Si Z.-Y., Smith M.J., Thomas W.D.;
RT   "Expression of the co-stimulatory molecule B7 on melanoma cells.";
RL   Int. J. Cancer 58:527-532(1994).
//
RX   PubMed=8980186; DOI=10.1002/(SICI)1097-0215(19961211)68:6<795::AID-IJC18>3.0.CO;2-#;
RA   Thomas W.D., Smith M.J., Si Z.-Y., Hersey P.;
RT   "Expression of the co-stimulatory molecule CD40 on melanoma cells.";
RL   Int. J. Cancer 68:795-801(1996).
//
RX   PubMed=9725211; DOI=10.4049/jimmunol.161.5.2195;
RA   Thomas W.D., Hersey P.;
RT   "TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in
RT   Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of
RT   target cells.";
RL   J. Immunol. 161:2195-2200(1998).
//
RX   PubMed=10364001;
RA   Zhang X.-D., Franco A., Myers K., Gray C., Nguyen T., Hersey P.;
RT   "Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor
RT   and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of
RT   melanoma.";
RL   Cancer Res. 59:2747-2753(1999).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M.,
RA   Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L.,
RA   Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G.,
RA   Meltzer P.S., Ringner M., Hayward N.K.;
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V.,
RA   Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M.,
RA   Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.;
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//