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Cellosaurus SKMEL28-SLC13A3-KO-c3 (CVCL_D4WQ)

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Cell line name SKMEL28-SLC13A3-KO-c3
Synonyms CE05P4-N
Accession CVCL_D4WQ
Resource Identification Initiative To cite this cell line use: SKMEL28-SLC13A3-KO-c3 (RRID:CVCL_D4WQ)
Comments Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14430; SLC13A3.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Web pages https://re-solute.eu/resources/reagents
Cross-references
Encyclopedic resources Wikidata; Q127384307
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3