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Cellosaurus LS180-SLCO1B3-KO-c10 (CVCL_D4WF)

[Text version]
Cell line name LS180-SLCO1B3-KO-c10
Synonyms CE00C3-E
Accession CVCL_D4WF
Resource Identification Initiative To cite this cell line use: LS180-SLCO1B3-KO-c10 (RRID:CVCL_D4WF)
Comments Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 10961; SLCO1B3.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0397 (LS180)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Web pages https://re-solute.eu/resources/reagents
Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1