Cellosaurus cell line HuH7-SLC15A1-KO-c6 (CVCL

Cross-references
Cell line name	HuH7-SLC15A1-KO-c6
Synonyms	CE07B0-B
Accession	CVCL_D4RT
Resource Identification Initiative	To cite this cell line use: HuH7-SLC15A1-KO-c6 (RRID:CVCL_D4RT)
Comments	Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel. Population: Japanese. Knockout cell: Method=CRISPR/Cas9; HGNC; 10920; SLC15A1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease	Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0336 (Huh-7)
Sex of cell	Male
Age at sampling	57Y
Category	Cancer cell line
Web pages	https://re-solute.eu/resources/reagents
Encyclopedic resources	Wikidata; Q127381841
Entry history
Entry creation	30-Jan-2024
Last entry update	10-Sep-2024
Version number	2