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Cellosaurus 1321N1-SLC4A8-KO-c4 (CVCL_D4FC)

[Text version]
Cell line name 1321N1-SLC4A8-KO-c4
Synonyms CE0573-1
Accession CVCL_D4FC
Resource Identification Initiative To cite this cell line use: 1321N1-SLC4A8-KO-c4 (RRID:CVCL_D4FC)
Comments Problematic cell line: Contaminated. Ancestral cell line (U-118MG) has been shown to be a U-138MG derivative.
Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11034; SLC4A8.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0110 (1321N1)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
Web pages Info; RESOLUTE; CE0573-1; https://re-solute.eu/resources/reagents
Cross-references
Encyclopedic resources Wikidata; Q127378611
Entry history
Entry creation30-Jan-2024
Last entry update10-Apr-2025
Version number4