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Cellosaurus M4A1-M2B9 (CVCL_D4AF)

[Text version]
Cell line name M4A1-M2B9
Accession CVCL_D4AF
Resource Identification Initiative To cite this cell line use: M4A1-M2B9 (RRID:CVCL_D4AF)
Comments Characteristics: Established from a patient-derived xenograft obtained by intrafemoral injection in NOD scid mice (PubMed=37051743).
Doubling time: 56.8 hours (Note=In 20% FCS) (PubMed=37051743); ~48 hours (DSMZ=ACC-967).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-967

Markers:
AmelogeninX,Y
CSF1PO9,11
D2S133823,25
D3S135816
D5S81811,13
D7S8208,11
D8S117911,14
D13S31712
D16S5399,12
D18S5114,15
D19S43313,14
D21S1129,30
FGA20,22
Penta D9
Penta E8,12
TH019
TPOX8,11
vWA17,18

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Publications

PubMed=37051743; DOI=10.3324/haematol.2022.281712; PMCID=PMC10542830
van Outersterp I., Hormann F.M., Hoogkamer A.Q., Boeree A., van den Broek S.A., den Boer M.L., Boer J.M.
Characterization of a novel MEF2D-BCL9 fusion-positive acute lymphoblastic leukemia cell line.
Haematologica 108:2859-2864(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-967
Encyclopedic resources Wikidata; Q127382727
Sequence databases EGA; EGAD00001009758
EGA; EGAD00001009759
Entry history
Entry creation30-Jan-2024
Last entry update10-Apr-2025
Version number4