Cellosaurus cell line 697-R (CVCL

Cross-references
Cell line name	697-R
Synonyms	697R
Accession	CVCL_D3Z6
Resource Identification Initiative	To cite this cell line use: 697-R (RRID:CVCL_D3Z6)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_66484; Silvestrol. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:8632; PBX1 + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-PBX1, E2A-PBX1 (from parent cell line).
Disease	Childhood B acute lymphoblastic leukemia (NCIt: C9140) B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347) B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0079 (697)
Sex of cell	Male
Age at sampling	12Y
Category	Cancer cell line
Publications	PubMed=21538216; DOI=10.1208/s12248-011-9276-7; PMCID=PMC3160166 Gupta S.V., Sass E.J., Davis M.E., Edwards R.B., Lozanski G., Heerema N.A., Lehman A., Zhang X.-L., Jarjoura D., Byrd J.C., Pan L., Chan K.K., Kinghorn A.D., Phelps M.A., Grever M.R., Lucas D.M. Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells. AAPS J. 13:357-364(2011)
Encyclopedic resources	Wikidata; Q127378766
Entry history
Entry creation	30-Jan-2024
Last entry update	19-Dec-2024
Version number	3