ID   TCC-Y
AC   CVCL_D3Z4
SY   TCC-Y / wr; TCCY; Tochigi Cancer Center-Y
DR   Wikidata; Q127384377
RX   Patent=WO2004094628A1;
RX   PubMed=11264164;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: 36 +- 3 hours (PubMed=11264164).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=11264164).
CC   Sequence variation: Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Thr531Tyrfs*10 (c.1589dup) (p.Thr532Tyrfs*10, c.1592dup); Zygosity=Homozygous (PubMed=35124168).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Val1003Ile (c.3007G>A); Zygosity=Heterozygous (PubMed=35124168).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
//
RX   Patent=WO2004094628A1;
RA   Sato Y., Nagao H.;
RT   "Imanitib-resistant Philadelphia chromosome-positive human acute
RT   lymphocytic leukemic cell line and utilization thereof.";
RL   Patent number WO2004094628A1, 04-Nov-2004.
//
RX   PubMed=11264164; DOI=10.1182/blood.V97.7.1999;
RA   Kano Y., Akutsu M., Tsunoda S., Mano H., Sato Y., Honma Y.,
RA   Furukawa Y.;
RT   "In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in
RT   combination with commonly used antileukemic agents.";
RL   Blood 97:1999-2007(2001).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//