ID   ARSI
AC   CVCL_D3X9
DR   Wikidata; Q127380237
RX   PubMed=36084691;
CC   Characteristics: Established from a xenograft that was obtain by transplantation of the tumor cells in female immunodeficient NSG (NOD.Cg-Prkdc[scid] l2rg[tm1Wjll]/SzJ) mouse (PubMed=36084691).
CC   Doubling time: ~24 hours (PubMed=36084691).
CC   Sequence variation: Gene deletion; HGNC; HGNC:6119; IRF4; Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:1699; CD79B; Simple; p.Tyr196Cys (c.587A>G); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:6119; IRF4; Simple; p.Gln60Lys (c.178C>A); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:6119; IRF4; Simple; p.Ser104Arg (c.312C>A); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu265Pro (c.794T>C); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.Glu123Gln (c.367G>C); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.Pro124Ser (c.370C>T); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.His159Tyr (c.475C>T); Zygosity=Heterozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.Ser166Phe (c.497C>T); Zygosity=Homozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.Leu220Val (c.658C>G); Zygosity=Homozygous (PubMed=36084691).
CC   Sequence variation: Mutation; HGNC; HGNC:8986; PIM1; Simple; p.Glu226Lys (c.676G>A); Zygosity=Homozygous (PubMed=36084691).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
DI   NCIt; C45194; Primary cutaneous diffuse large B-cell lymphoma, leg type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   85Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
//
RX   PubMed=36084691; DOI=10.1016/j.jid.2022.08.043;
RA   Prochazkova-Carlotti M., Gros A., Richard E., Cherrier F.,
RA   Laharanne E., Idrissi Y., Baron C., Poglio S., Ducharme O., Menguy S.,
RA   Pham-Ledard A., Beylot-Barry M., Merlio J.-P., Bresson-Bepoldin L.;
RT   "Patient-derived xenograft and cell line models of human primary
RT   cutaneous diffuse large B-cell lymphoma-leg type.";
RL   J. Invest. Dermatol. 143:340-344.e6(2023).
//