ID   CGH-RPE.3b
AC   CVCL_D3WX
SY   RPE.3b
DR   Wikidata; Q127380459
RX   PubMed=6717439;
RX   PubMed=6928655;
CC   Characteristics: This is a class II Pseudomonas toxin resistant cell line. The resistance of class II mutants cannot be overcome by increased concentration of the toxin. They possess a mutationally altered EF-2 which does not serve as a substrate for ADP-ribosylation by the Pseudomonas toxin (PubMed=6928655).
CC   Selected for resistance to: UniProtKB; P11439; Pseudomonas aeruginosa exotoxin A (eta).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D3VX ! CHO-K1c
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 30-01-24; Last updated: 10-09-24; Version: 2
//
RX   PubMed=6717439; DOI=10.1128/mcb.4.4.642-650.1984; PMCID=PMC368773;
RA   Moehring T.J., Danley D.E., Moehring J.M.;
RT   "In vitro biosynthesis of diphthamide, studied with mutant Chinese
RT   hamster ovary cells resistant to diphtheria toxin.";
RL   Mol. Cell. Biol. 4:642-650(1984).
//
RX   PubMed=6928655; DOI=10.1073/pnas.77.2.1010; PMCID=PMC348413;
RA   Moehring J.M., Moehring T.J., Danley D.E.;
RT   "Posttranslational modification of elongation factor 2 in
RT   diphtheria-toxin-resistant mutants of CHO-K1 cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:1010-1014(1980).
//