ID   CH-RE1.22c-A3P2
AC   CVCL_D3WH
SY   CH-RE1.22cA3P2
DR   Wikidata; Q127380447
RX   PubMed=6928655;
CC   Characteristics: This is a class II diphtheria toxin resistant cell line. The resistance of class II mutants cannot be overcome by increased concentration of the toxin. They possess a mutationally altered EF-2 which does not serve as a substrate for ADP-ribosylation by diphtheria toxin (from parent cell line).
CC   Selected for resistance to: UniProtKB; P00588; Corynephage beta diphtheria toxin.
CC   Sequence variation: Mutation; UniProtKB; P09445; EEF2; Simple; p.Gly717Arg (c.2149G>A); Zygosity=Homozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D3WG ! CH-RE1.22c
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 30-01-24; Last updated: 10-09-24; Version: 2
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RX   PubMed=6928655; DOI=10.1073/pnas.77.2.1010; PMCID=PMC348413;
RA   Moehring J.M., Moehring T.J., Danley D.E.;
RT   "Posttranslational modification of elongation factor 2 in
RT   diphtheria-toxin-resistant mutants of CHO-K1 cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:1010-1014(1980).
//