ID   ZR/HERc 1G
AC   CVCL_D3WD
SY   ZR-HERc 1G
DR   Wikidata; Q127384788
RX   PubMed=1516065;
CC   Population: Caucasian.
CC   Characteristics: Expresses EGFR under the control of HSV-1 TK promoter (PubMed=1516065).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 14-08-25; Version: 4
//
RX   PubMed=1516065;
RA   van Agthoven, Ton
RA   van Agthoven, Thecla L.A.
RA   Portengen, Henk
RA   Foekens, John A.
RA   Dorssers, Lambert C.J.
RT   "Ectopic expression of epidermal growth factor receptors induces
RT   hormone independence in ZR-75-1 human breast cancer cells.";
RL   Cancer Res. 52:5082-5088(1992).
//