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Cellosaurus LNCaP-r (CVCL_D3W5)

[Text version]
Cell line name LNCaP-r
Accession CVCL_D3W5
Resource Identification Initiative To cite this cell line use: LNCaP-r (RRID:CVCL_D3W5)
Comments Population: Caucasian.
Characteristics: Resistant to androgen (PubMed=4048015).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=4048015; DOI=10.1002/pros.2990070208
Hasenson M., Hartley-Asp B., Kihlfors C., Lundin A., Gustafsson J.-A., Pousette A.
Effect of hormones on growth and ATP content of a human prostatic carcinoma cell line, LNCaP-r.
Prostate 7:183-194(1985)

PubMed=2734981; DOI=10.1007/BF00262025
Konig J.J., Kamst E., Hagemeijer A., Romijn J.C., Horoszewicz J.S., Schroder F.H.
Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP.
Urol. Res. 17:79-86(1989)

PubMed=10092147; DOI=10.1007/s002400050082
Konig J.J., Teubel W.J., van Steenbrugge G.J., Romijn J.C., Hagemeijer A.
Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines.
Urol. Res. 27:3-8(1999)

Cross-references
Encyclopedic resources Wikidata; Q127382614
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3