Cell line name |
LNCaP-r |
Accession |
CVCL_D3W5 |
Resource Identification Initiative |
To cite this cell line use: LNCaP-r (RRID:CVCL_D3W5) |
Comments |
Population: Caucasian. Characteristics: Resistant to androgen (PubMed=4048015). Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
Disease |
Prostate carcinoma (NCIt: C4863) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1379 (LNCaP clone FGC) |
Sex of cell |
Male |
Age at sampling |
50Y |
Category |
Cancer cell line |
Publications | PubMed=4048015; DOI=10.1002/pros.2990070208 Hasenson M., Hartley-Asp B., Kihlfors C., Lundin A., Gustafsson J.-A., Pousette A. Effect of hormones on growth and ATP content of a human prostatic carcinoma cell line, LNCaP-r. Prostate 7:183-194(1985) PubMed=2734981; DOI=10.1007/BF00262025 Konig J.J., Kamst E., Hagemeijer A., Romijn J.C., Horoszewicz J.S., Schroder F.H. Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP. Urol. Res. 17:79-86(1989) PubMed=10092147; DOI=10.1007/s002400050082 Konig J.J., Teubel W.J., van Steenbrugge G.J., Romijn J.C., Hagemeijer A. Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines. Urol. Res. 27:3-8(1999) |
Cross-references |
Encyclopedic resources |
Wikidata; Q127382614
|
Entry history |
Entry creation | 30-Jan-2024 |
Last entry update | 19-Dec-2024 |
Version number | 3 |
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