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Cellosaurus A549 PIP4P1 KO (CVCL_D3VW)

[Text version]
Cell line name A549 PIP4P1 KO
Synonyms A549 TMEM55B KO
Accession CVCL_D3VW
Resource Identification Initiative To cite this cell line use: A549 PIP4P1 KO (RRID:CVCL_D3VW)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:19299; PIP4P1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

DOI=10.1101/2023.06.07.544051
Pal P., Taylor M., Lam P.Y., Tonelli F., Hecht C.A., Lis P., Nirujogi R.S., Phung T.K., Dickie E.A., Wightman M., Macartney T., Pfeffer S.R., Alessi D.R.
Parkinson's VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B.
bioRxiv 2023:06.07.544051-06.07.544051(2023)

Cross-references
Encyclopedic resources Wikidata; Q127378819
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3