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Cellosaurus iBMK BIM-/- A.Raf-B (CVCL_D3KR)

[Text version]
Cell line name iBMK BIM-/- A.Raf-B
Synonyms BIM-/- A.Raf-B
Accession CVCL_D3KR
Resource Identification Initiative To cite this cell line use: iBMK BIM-/- A.Raf-B (RRID:CVCL_D3KR)
Comments Knockout cell: Method=KO mouse; MGI; MGI:1197519; Bcl2l11.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9829; RAF1 (Note=With at the C-terminus the addition of the C-terminal 18 AA of KRAS isoform 2B/K-Ras4B = Raf-CAAX).
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03255; Adenovirus 5 E1A protein.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5 (Note=E1A).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_D3KE (iBMK BIM-/- A)
Age at sampling <2D
Category Transformed cell line
Publications

PubMed=15766661; DOI=10.1016/j.ccr.2005.02.008
Tan T.-T., Degenhardt K., Nelson D.A., Beaudoin B., Nieves-Neira W., Bouillet P., Villunger A., Adams J.M., White E.
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell 7:227-238(2005)

PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4
Mathew R., Degenhardt K., Haramaty L., Karp C.M., White E.
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer.
Methods Enzymol. 446:77-106(2008)

Cross-references
Encyclopedic resources Wikidata; Q127382147
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3