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Cellosaurus iBMK W2.Akt-D1 (CVCL_D3GZ)

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Cell line name iBMK W2.Akt-D1
Synonyms W2.Akt-D1; W2.AKT-D1; W2 AKT D1
Accession CVCL_D3GZ
Resource Identification Initiative To cite this cell line use: iBMK W2.Akt-D1 (RRID:CVCL_D3GZ)
Comments Knockout cell: Method=KO mouse; MGI; MGI:99702; Bax (Note=1 of 2 alleles).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:391; AKT1 (Note=Myristoylated = myr-AKT).
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Adenovirus 5 E1A protein.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5 (Note=E1A).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_D3G2 (iBMK W2)
Sex of cell Sex unspecified
Age at sampling 5D
Category Transformed cell line
Publications

PubMed=15766661; DOI=10.1016/j.ccr.2005.02.008
Tan T.-T., Degenhardt K., Nelson D.A., Beaudoin B., Nieves-Neira W., Bouillet P., Villunger A., Adams J.M., White E.
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell 7:227-238(2005)

PubMed=16843265; DOI=10.1016/j.ccr.2006.06.001; PMCID=PMC2857533
Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G.-H., Mukherjee C., Shi Y.-F., Gelinas C., Fan Y.-J., Nelson D.A., Jin S.-K., White E.
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.
Cancer Cell 10:51-64(2006)

PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4
Mathew R., Degenhardt K., Haramaty L., Karp C.M., White E.
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer.
Methods Enzymol. 446:77-106(2008)

Cross-references
Encyclopedic resources Wikidata; Q127382253
Entry history
Entry creation30-Jan-2024
Last entry update10-Apr-2025
Version number4