ID   iBMK D3.Hras-1
AC   CVCL_D3GI
SY   D3.Hras-1; D3 Hras-1
DR   Wikidata; Q127382193
RX   PubMed=15766661;
RX   PubMed=16843265;
RX   PubMed=18603117;
CC   Knockout cell: Method=KO mouse; MGI; MGI:1097161; Bak1.
CC   Knockout cell: Method=KO mouse; MGI; MGI:99702; Bax.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_D3FV ! iBMK D3
SX   Sex unspecified
AG   5D
CA   Transformed cell line
DT   Created: 30-01-24; Last updated: 14-08-25; Version: 5
CH   CVCL_D3JC ! iBMK D3.Hras-1RED-10
CH   CVCL_D3JA ! iBMK D3.Hras-1RED-2
CH   CVCL_D3JB ! iBMK D3.Hras-1RED-7
//
RX   PubMed=16843265; DOI=10.1016/j.ccr.2006.06.001; PMCID=PMC2857533;
RA   Degenhardt, Kurt
RA   Mathew, Robin
RA   Beaudoin, Brian
RA   Bray, Kevin
RA   Anderson, Diana
RA   Chen, Guang-Hua
RA   Mukherjee, Chandreyee
RA   Shi, Yu-Fang
RA   Gelinas, Celine
RA   Fan, Yong-Jun
RA   Nelson, Deirdre A.
RA   Jin, Sheng-Kan
RA   White, Eileen
RT   "Autophagy promotes tumor cell survival and restricts necrosis,
RT   inflammation, and tumorigenesis.";
RL   Cancer Cell 10:51-64(2006).
//
RX   PubMed=15766661; DOI=10.1016/j.ccr.2005.02.008;
RA   Tan, Ting-Ting
RA   Degenhardt, Kurt
RA   Nelson, Deirdre A.
RA   Beaudoin, Brian
RA   Nieves-Neira, Wilberto
RA   Bouillet, Philippe
RA   Villunger, Andreas
RA   Adams, Jerry McKee
RA   White, Eileen
RT   "Key roles of BIM-driven apoptosis in epithelial tumors and rational
RT   chemotherapy.";
RL   Cancer Cell 7:227-238(2005).
//
RX   PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4;
RA   Mathew, Robin
RA   Degenhardt, Kurt
RA   Haramaty, Liti
RA   Karp, Cristina M.
RA   White, Eileen
RT   "Immortalized mouse epithelial cell models to study the role of
RT   apoptosis in cancer.";
RL   Methods Enzymol. 446:77-106(2008).
//