Cellosaurus BU2:N1 (CVCL_D2WH)
Cell line name | BU2:N1 |
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Synonyms | BU2 N1; BU2-TetOn:NICD |
Accession | CVCL_D2WH |
Resource Identification Initiative | To cite this cell line use: BU2:N1 (RRID:CVCL_D2WH) |
Comments | From: Boston University School of Medicine; Boston; USA. Population: Caucasian. Characteristics: Under the control of doxycycline expresses the intracellular domain of the NOTCH1 receptor (NICD1). Using ZFN a construct containing a reverse tetracycline-controlled transactivator (rtTA), NICD1 and puroR was inserted in the AAVS1 safe harbor locus (PubMed=36332629). Transfected with: HGNC; 7881; NOTCH1 (with p.Met1_Arg1762del = NICD1). Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR. Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del). Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
Hierarchy | Parent: CVCL_JW25 (CREM002i-BU2C10) |
Sex of cell | Male |
Age at sampling | 45Y |
Category | Induced pluripotent stem cell |
Web pages | https://stemcellbank.bu.edu/Catalog/Item/Details/782 |
Publications | PubMed=36332629; DOI=10.1016/j.stemcr.2022.10.007 |
Entry history | |
Entry creation | 30-Jan-2024 |
Last entry update | 30-Jan-2024 |
Version number | 1 |