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Cellosaurus LN229/hPDPN (CVCL_D2U6)

[Text version]
Cell line name LN229/hPDPN
Accession CVCL_D2U6
Resource Identification Initiative To cite this cell line use: LN229/hPDPN (RRID:CVCL_D2U6)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 29602; PDPN.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Brain, right frontal parieto-occipital cortex.
Sequence variations
  • Mutation; HGNC; 6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0393 (LN-229)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=25080943; DOI=10.1038/srep05924; PMCID=PMC4118152
Kato Y., Kaneko M.K.
A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin.
Sci. Rep. 4:5924-5924(2014)

PubMed=26492619; DOI=10.1089/mab.2015.0018
Ogasawara S., Oki H., Kaneko M.K., Hozumi Y., Liu X., Honma R., Fujii Y., Nakamura T., Goto K., Takagi M., Kato Y.
Development of monoclonal antibody LpMab-10 recognizing non-glycosylated PLAG1/2 domain including Thr34 of human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 34:318-326(2015)

PubMed=26937552; DOI=10.1089/mab.2015.0077
Kato Y., Ogasawara S., Oki H., Honma R., Takagi M., Fujii Y., Nakamura T., Saidoh N., Kanno H., Umetsu M., Kamata S., Kubo H., Yamada M., Sawa Y., Morita K.-i., Harada H., Suzuki H., Kaneko M.K.
Novel monoclonal antibody LpMab-17 developed by CasMab technology distinguishes human podoplanin from monkey podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 35:109-116(2016)

PubMed=27031228; DOI=10.1371/journal.pone.0152912; PMCID=PMC4816300
Kato Y., Ogasawara S., Oki H., Goichberg P., Honma R., Fujii Y., Kaneko M.K.
LpMab-12 established by CasMab technology specifically detects sialylated O-glycan on Thr52 of platelet aggregation-stimulating domain of human podoplanin.
PLoS ONE 11:E0152912-E0152912(2016)

PubMed=27328060; DOI=10.1089/mab.2016.0006
Ogasawara S., Kaneko M.K., Honma R., Oki H., Fujii Y., Takagi M., Suzuki H., Kato Y.
Establishment of mouse monoclonal antibody LpMab-13 against human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 35:155-162(2016)

PubMed=27564251; DOI=10.1089/mab.2016.0031
Ogasawara S., Kaneko M.K., Kato Y.
LpMab-19 recognizes sialylated O-Glycan on Thr76 of human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 35:245-253(2016)

PubMed=28101903; DOI=10.1002/cam4.954; PMCID=PMC5313638
Kaneko M.K., Nakamura T., Honma R., Ogasawara S., Fujii Y., Abe S., Takagi M., Harada H., Suzuki H., Nishioka Y., Kato Y.
Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN.
Cancer Med. 6:382-396(2017)

PubMed=28387591; DOI=10.1089/mab.2017.0001
Yamada S., Ogasawara S., Kaneko M.K., Kato Y.
LpMab-23: a cancer-specific monoclonal antibody against human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 36:72-76(2017)

Patent=US10227407
Kato Y., Kaneko M.K.
Anti-podoplanin antibody.
Patent number US10227407, 12-Mar-2019

Cross-references
Encyclopedic resources Wikidata; Q127382607
Entry history
Entry creation30-Jan-2024
Last entry update10-Sep-2024
Version number2