| Cell line name |
LN229/PODXL |
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| Synonyms |
LN229/hPODXL |
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| Accession |
CVCL_D2TU |
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| Resource Identification Initiative |
To cite this cell line use: LN229/PODXL (RRID:CVCL_D2TU) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 9171; PODXL.
Derived from site: In situ; Brain, right frontal parieto-occipital cortex. |
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| Sequence variations |
- Mutation; HGNC; 6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
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| Disease |
Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0393 (LN-229) |
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| Sex of cell |
Female |
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| Age at sampling |
60Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=28384052; DOI=10.1089/mab.2017.0008; PMCID=PMC5404275
Ogasawara S., Kaneko M.K., Yamada S., Honma R., Nakamura T., Saidoh N., Yanaka M., Yoshida K., Fujii Y., Kato Y.
PcMab-47: novel antihuman podocalyxin monoclonal antibody for immunohistochemistry.
Monoclon. Antib. Immunodiagn. Immunother. 36:50-56(2017) PubMed=33088928; DOI=10.1016/j.bbrep.2020.100826; PMCID=PMC7559861
Kaneko M.K., Ohishi T., Kawada M., Kato Y.
A cancer-specific anti-podocalyxin monoclonal antibody (60-mG(2a)-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma.
Biochem. Biophys. Rep. 24:100826.1-100826.7(2020) Patent=US10906972
Kato Y., Kaneko M.K., Ogasawara S.
Cancer cell specific anti-podocalyxin antibody and method for producing same.
Patent number US10906972, 02-Feb-2021 |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q127382613
|
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| Entry history |
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| Entry creation | 30-Jan-2024 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 2 |
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