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Cellosaurus LN229/EGFR (CVCL_D2SN)

[Text version]
Cell line name LN229/EGFR
Accession CVCL_D2SN
Resource Identification Initiative To cite this cell line use: LN229/EGFR (RRID:CVCL_D2SN)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3236; EGFR (Note=With a N-terminal GVAMPGAEDDVV = PA-tag and a C-terminal with a C-terminal DMVNPGLEDRIE = RAP-tag and GDGMVPPGIEDK = MAP-tag).
Derived from site: In situ; Brain, right frontal parieto-occipital cortex.
Sequence variations
  • Mutation; HGNC; 6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0393 (LN-229)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=29090976; DOI=10.1089/mab.2017.0042; PMCID=PMC6975130
Itai S., Yamada S., Kaneko M.K., Chang Y.-W., Harada H., Kato Y.
Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity.
Monoclon. Antib. Immunodiagn. Immunother. 36:272-281(2017)

PubMed=32218834; DOI=10.3892/ol.2020.11384; PMCID=PMC7068343
Takei J., Kaneko M.K., Ohishi T., Kawada M., Harada H., Kato Y.
A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor activity against oral squamous cell carcinomas via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.
Oncol. Lett. 19:2809-2816(2020)

Cross-references
Encyclopedic resources Wikidata; Q127382604
Entry history
Entry creation30-Jan-2024
Last entry update10-Sep-2024
Version number2