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Cellosaurus HBT-3 (CVCL_D281)

[Text version]
Cell line name HBT-3
Synonyms HBT3
Accession CVCL_D281
Resource Identification Initiative To cite this cell line use: HBT-3 (RRID:CVCL_D281)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=1246601; PubMed=4469665; PubMed=20143388). Originally thought to originate from a breast carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00052.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_U962 (G-11)CVCL_M746 (HBT-E)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=4344270; DOI=10.3181/00379727-141-36850
Bassin R.H., Plata E.J., Gerwin B.I., Mattern C.F.T., Haapala D.K., Chu E.W.
Isolation of a continuous epithelioid cell line, HBT-3, from a human breast carcinoma.
Proc. Soc. Exp. Biol. Med. 141:673-680(1972)

PubMed=4469665; DOI=10.1126/science.184.4141.1093
Nelson-Rees W.A., Flandermeyer R.R., Hawthorne P.K.
Banded marker chromosomes as indicators of intraspecies cellular contamination.
Science 184:1093-1096(1974)

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York; USA (1975)

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

CLPUB00262
Gold M.
A conspiracy of cells. One woman's immortal legacy and the medical scandal it caused.
(In book) ISBN 9780887060991; pp.1-171; State University of New York Press; Albany; USA (1986)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151699
Encyclopedic resources Wikidata; Q54881458
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number21