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Cellosaurus MDA-MB-231-luc-D3H2LN (CVCL_D257)

[Text version]
Cell line name MDA-MB-231-luc-D3H2LN
Synonyms D3H2LN
Accession CVCL_D257
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc-D3H2LN (RRID:CVCL_D257)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Expression of firefly luciferase is under the control of a SV40 promoter (PerkinElmer=119369).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D88 (MDA-MB-231-luc-D3H1)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Web pages https://web.archive.org/web/20150202002416/http://www.perkinelmer.com/catalog/product/id/119369
Publications

PubMed=15987449; DOI=10.1186/bcr1026; PMCID=PMC1175057
Jenkins D.E., Hornig Y.S., Oei Y.A., Dusich J.M., Purchio T.
Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice.
Breast Cancer Res. 7:R444-R454(2005)

Cross-references
Cell line collections (Providers) PerkinElmer; 119369 - Discontinued
Cell line databases/resources cancercelllines; CVCL_D257
Encyclopedic resources Wikidata; Q54904599
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number28