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Cellosaurus LiM6 (CVCL_D240)

[Text version]
Cell line name LiM6
Synonyms LIM6; LiM-6; LS-LiM6; Ls-LiM6; LS LiM 6; LS LiM6; LSLiM6
Accession CVCL_D240
Resource Identification Initiative To cite this cell line use: LiM6 (RRID:CVCL_D240)
Comments Population: Caucasian.
Characteristics: Has high liver-metastasizing ability during cecal growth, was established from parent cell line by serially selecting cells which metastasized from cecum to liver (PubMed=1999484).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line

PubMed=3032811; DOI=10.1002/ijc.2910390514
Bresalier R.S., Raper S.E., Hujanen E.S., Kim Y.S.
A new animal model for human colon cancer metastasis.
Int. J. Cancer 39:625-630(1987)

PubMed=1999484; DOI=10.1172/JCI115063
Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W., Rockwell R.W., Dahiya R., Kim Y.S.
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

PubMed=21941373; DOI=10.1038/cdd.2011.123
Mazurek N., Byrd J.C., Sun Y., Hafley M., Ramirez K., Burks J., Bresalier R.S.
Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells.
Cell Death Differ. 19:523-533(2012)

Cell line databases/resources cancercelllines; CVCL_D240
Anatomy/cell type resources BTO; BTO:0004866
Encyclopedic resources Wikidata; Q54902542
Polymorphism and mutation databases Cosmic; 1132697
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number18