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Cellosaurus MGG8 (CVCL_D1H4)

[Text version]
Cell line name MGG8
Synonyms MGG-8
Accession CVCL_D1H4
Resource Identification Initiative To cite this cell line use: MGG8 (RRID:CVCL_D1H4)
Comments Group: Cancer stem cell line.
Omics: Array-based CGH.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=22067563).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (PubMed=22067563).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22067563; DOI=10.1093/neuonc/nor195
Wakimoto H., Mohapatra G., Kanai R., Curry W.T. Jr., Yip S., Nitta M., Patel A.P., Barnard Z.R., Stemmer-Rachamimov A.O., Louis D.N., Martuza R.L., Rabkin S.D.
Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.
Neuro-oncol. 14:132-144(2012)

PubMed=24726434; DOI=10.1016/j.cell.2014.02.030
Suva M.L., Rheinbay E., Gillespie S.M., Patel A.P., Wakimoto H., Rabkin S.D., Riggi N., Chi A.S., Cahill D.P., Nahed B.V., Curry W.T. Jr., Martuza R.L., Rivera M.N., Rossetti N., Kasif S., Beik S., Kadri S., Tirosh I., Wortman I., Shalek A.K., Rozenblatt-Rosen O., Regev A., Louis D.N., Bernstein B.E.
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
Cell 157:580-594(2014)

PubMed=27564115; DOI=10.18632/oncotarget.11589
Wilson T.J., Zamler D.B., Doherty R., Castro M.G., Lowenstein P.R.
Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool.
Oncotarget 7:63020-63041(2016)

Cross-references
Anatomy/cell type resources BTO; BTO:0006545
Gene expression databases GEO; GSM1306341
GEO; GSM1306344
GEO; GSM1324081
GEO; GSM1324082
GEO; GSM1324083
GEO; GSM1324090
GEO; GSM1324091
GEO; GSM1324092
GEO; GSM1324093
GEO; GSM1324094
GEO; GSM1324095
GEO; GSM1324096
GEO; GSM1324097
Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1