ID   10-15
AC   CVCL_D1H0
SY   NMC1015
DR   BioGRID_ORCS_Cell_line; 793
DR   Wikidata; Q127378552
RX   PubMed=23604113;
RX   PubMed=24736545;
RX   PubMed=30135075;
CC   Sequence variation: Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=23604113; PubMed=24736545).
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
//
RX   PubMed=23604113; DOI=10.1038/onc.2013.126; PMCID=PMC3942361;
RA   Grayson A.R., Walsh E.M., Cameron M.J., Godec J., Ashworth T.,
RA   Ambrose J.M., Aserlind A.B., Wang H., Evan G.I., Kluk M.J.,
RA   Bradner J.E., Aster J.C., French C.A.;
RT   "MYC, a downstream target of BRD-NUT, is necessary and sufficient for
RT   the blockade of differentiation in NUT midline carcinoma.";
RL   Oncogene 33:1736-1742(2014).
//
RX   PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982;
RA   Wang R.-R., Liu W., Helfer C.M., Bradner J.E., Hornick J.L.,
RA   Janicki S.M., French C.A., You J.-X.;
RT   "Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives
RT   neoplastic transformation in NUT midline carcinoma.";
RL   Cancer Res. 74:3332-3343(2014).
//
RX   PubMed=30135075; DOI=10.1101/gad.315648.118; PMCID=PMC6120715;
RA   Liao S., Maertens O., Cichowski K.M., Elledge S.J.;
RT   "Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma
RT   uncovers a synergism between BETis and CDK4/6is.";
RL   Genes Dev. 32:1188-1200(2018).
//