ID   hIPSC-Tri21-C3-1
AC   CVCL_D1FA
SY   Tri C3-1; C3-1
DR   Wikidata; Q127381767
RX   PubMed=23084023;
CC   Population: Caucasian.
CC   Characteristics: Using CRISPR/Cas9 a IRES-TK-Neo-polyA site cassette was introduced in one allele of exon 3 of APP on chromosome 21 (PubMed=23084023).
CC   Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Chest, skin; UBERON=UBERON_0001868.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X867 ! AG06872
SX   Female
AG   1Y
CA   Induced pluripotent stem cell
DT   Created: 30-01-24; Last updated: 10-09-24; Version: 2
//
RX   PubMed=23084023; DOI=10.1016/j.stem.2012.08.004; PMCID=PMC3705773;
RA   Li L.B., Chang K.-H., Wang P.-R., Hirata R.K., Papayannopoulou T.,
RA   Russell D.W.;
RT   "Trisomy correction in Down syndrome induced pluripotent stem cells.";
RL   Cell Stem Cell 11:615-619(2012).
//