ID   RW-2982
AC   CVCL_D174
SY   RW2982
DR   cancercelllines; CVCL_D174
DR   ColonAtlas; RW2982
DR   Cosmic; 1479600
DR   Cosmic; 1676748
DR   Cosmic; 1803949
DR   Cosmic; 2302004
DR   GEO; GSM1346885
DR   Wikidata; Q54951483
RX   CelloPub=CLPUB00125;
RX   PubMed=2837323;
RX   PubMed=8422623;
RX   PubMed=20570890;
RX   PubMed=24755471;
RX   PubMed=25944804;
CC   Population: Caucasian.
CC   Doubling time: 58.41 hours (PubMed=25944804).
CC   Microsatellite instability: Stable (MSS) (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu1309Ter (c.3925G>T); ClinVar=VCV000824390; Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000045115; Zygosity=Unspecified (PubMed=20570890; PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Cys363Tyr (c.1088G>A); ClinVar=VCV000233663; Zygosity=Unspecified (PubMed=24755471).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
DI   NCIt; C7966; Colon mucinous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 18
//
RX   CelloPub=CLPUB00125;
RA   Tibbetts L.M., Chu M.Y., Spremulli E.N., Leduc E.H., Calabresi P.;
RT   "Loss and restoration of tumorigenicity in a human mesothelioma cell
RT   line.";
RL   Proc. Am. Assoc. Cancer Res. 25:45-45(1984).
//
RX   PubMed=2837323;
RA   Tibbetts L.M., Chu M.Y., Vezeridis M.P., Miller P.G., Tibbetts L.L.,
RA   Poisson M.H., Camara P.D., Calabresi P.;
RT   "Cell culture of the mucinous variant of human colorectal carcinoma.";
RL   Cancer Res. 48:3751-3759(1988).
//
RX   PubMed=8422623; DOI=10.1002/1097-0142(19930115)71:2<315::AID-CNCR2820710208>3.0.CO;2-B;
RA   Tibbetts L.M., Doremus C.M., Tzanakakis G.N., Vezeridis M.P.;
RT   "Liver metastases with 10 human colon carcinoma cell lines in nude
RT   mice and association with carcinoembryonic antigen production.";
RL   Cancer 71:315-321(1993).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192;
RA   Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S.,
RA   Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M.,
RA   Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M.,
RA   Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.;
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013;
RA   Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S.,
RA   Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S.,
RA   O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F.,
RA   Mariadason J.M., Sieber O.M.;
RT   "Colorectal cancer cell lines are representative models of the main
RT   molecular subtypes of primary cancer.";
RL   Cancer Res. 74:3238-3247(2014).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E.,
RA   Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R.,
RA   Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.;
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//