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Cellosaurus SCN2.2 (CVCL_D050)

[Text version]
Cell line name SCN2.2
Synonyms SCN 2.2
Accession CVCL_D050
Resource Identification Initiative To cite this cell line use: SCN2.2 (RRID:CVCL_D050)
Comments Characteristics: Capable to differentiate into different phenotypes. Expresses the neuronal markers (NSE, PGP and MAP2), but absent of glial markers. Valuable tool for studies relating to the regulation of the central mammalian pacemaker function and the development of the suprachiasmatic nucleus (SCN) cell types (Kerafast=EUT500).
Doubling time: 28 hours (PubMed=10213449).
Transformant: Psi2 defective retrovirus adenovirus E1A.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Embryonic brain, hypothalamus, suprachiasmatic nucleus; UBERON=UBERON_0006238+UBERON_0002034.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Long-Evans; RS=RS_0000347.
Sex of cell Sex unspecified
Age at sampling 15-16FD
Category Transformed cell line
Publications

PubMed=10213449; DOI=10.1002/(SICI)1097-4695(199904)39:1<1::AID-NEU1>3.0.CO;2-F
Earnest D.J., Liang F.-Q., DiGiorgio S., Gallagher M., Harvey B.K., Earnest B., Seigel G.M.
Establishment and characterization of adenoviral E1A immortalized cell lines derived from the rat suprachiasmatic nucleus.
J. Neurobiol. 39:1-13(1999)

PubMed=15769907; DOI=10.1152/physiolgenomics.00224.2004
Menger G.J., Lu K., Thomas T.L., Cassone V.M., Earnest D.J.
Circadian profiling of the transcriptome in immortalized rat SCN cells.
Physiol. Genomics 21:370-381(2005)

PubMed=17284666; DOI=10.1152/physiolgenomics.00199.2006
Menger G.J., Allen G.C., Neuendorff N., Nahm S.-S., Thomas T.L., Cassone V.M., Earnest D.J.
Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN.
Physiol. Genomics 29:280-289(2007)

Cross-references
Cell line collections (Providers) ABM; T0296
CancerTools; 160400
Kerafast; EUT500
Encyclopedic resources Wikidata; Q54952478
Experimental variables resources EFO; EFO_0002708
Gene expression databases GEO; GSM28447
GEO; GSM28448
GEO; GSM28449
GEO; GSM28450
GEO; GSM28451
GEO; GSM28452
GEO; GSM28453
GEO; GSM28454
GEO; GSM28455
GEO; GSM28456
GEO; GSM28458
GEO; GSM28459
GEO; GSM28460
GEO; GSM28461
GEO; GSM28462
GEO; GSM28463
GEO; GSM28464
GEO; GSM28465
GEO; GSM28466
GEO; GSM28467
GEO; GSM28468
GEO; GSM28469
GEO; GSM28470
GEO; GSM28471
GEO; GSM28472
GEO; GSM28473
GEO; GSM28474
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number14