| Cell line name |
M18/B7 |
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| Accession |
CVCL_D030 |
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| Resource Identification Initiative |
To cite this cell line use: M18/B7 (RRID:CVCL_D030) |
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| Comments |
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1700; CD80. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Unspecified (from parent cell line).
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| HLA typing |
Source: PubMed=15592718
| Class I | | HLA-A | A*29:02:01,29:02:01 | | HLA-B | B*49:01,49:01 | | HLA-C | C*07:01:01,07:01:01 | | Class II | | HLA-DP | DPB1*02:01:02,03:01:01 | | HLA-DQ | DQB1*03:02,03:01:01 | | HLA-DR | DRB1*04:05:01,04:07:01 |
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| Disease |
Cutaneous melanoma (NCIt: C3510) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_D029 (M18) |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ESTDAB=ESTDAB-041
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005) PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello Osuna F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_D030
ESTDAB; ESTDAB-041
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| Encyclopedic resources |
Wikidata; Q54903494
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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