ID   DS1-iPS4
AC   CVCL_D012
SY   DS1-IPS4
DR   Wikidata; Q54831438
RX   Patent=US20110151447;
RX   PubMed=18691744;
RX   PubMed=22344463;
RX   PubMed=23045682;
CC   From: Children's Hospital Boston; Boston; USA.
CC   Population: Caucasian.
CC   Derived from site: In situ; Chest, skin; UBERON=UBERON_0001868.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_L780 ! AG05397
SX   Male
AG   1Y
CA   Induced pluripotent stem cell
DT   Created: 22-10-12; Last updated: 10-09-24; Version: 16
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RX   Patent=US20110151447;
RA   Park I.-H., Daley G.Q., Agarwal S., Lerou P.H.;
RT   "Method to produce induced pluripotent stem (iPS) cells from
RT   non-embryonic human cells.";
RL   Patent number US20110151447, 23-Jun-2011.
//
RX   PubMed=18691744; DOI=10.1016/j.cell.2008.07.041; PMCID=PMC2633781;
RA   Park I.-H., Arora N., Huo H.-G., Maherali N., Ahfeldt T., Shimamura A.,
RA   Lensch M.W., Cowan C.A., Hochedlinger K., Daley G.Q.;
RT   "Disease-specific induced pluripotent stem cells.";
RL   Cell 134:877-886(2008).
//
RX   PubMed=22344463; DOI=10.1126/scitranslmed.3003771; PMCID=PMC4129935;
RA   Shi Y.-C., Kirwan P., Smith J., MacLean G.A., Orkin S.H., Livesey F.J.;
RT   "A human stem cell model of early Alzheimer's disease pathology in
RT   Down syndrome.";
RL   Sci. Transl. Med. 4:124ra29.1-124ra29.9(2012).
//
RX   PubMed=23045682; DOI=10.1073/pnas.1215468109; PMCID=PMC3491455;
RA   MacLean G.A., Menne T.F., Guo G.-J., Sanchez D.J., Park I.-H.,
RA   Daley G.Q., Orkin S.H.;
RT   "Altered hematopoiesis in trisomy 21 as revealed through in vitro
RT   differentiation of isogenic human pluripotent cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:17567-17572(2012).
//