Cellosaurus cell line ES-2/TxT50 (CVCL

Cellosaurus ES-2/TxT50 (CVCL_CZ95)

Cross-references
Cell line name	ES-2/TxT50
Synonyms	ES-2 TxT50; ES-2TxT50
Accession	CVCL_CZ95
Resource Identification Initiative	To cite this cell line use: ES-2/TxT50 (RRID:CVCL_CZ95)
Comments	Problematic cell line: Probably misclassified. Parent cell line seems to originate from a Caucasian patient with an ovarian serous adenocarcinoma origin. Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:4672; Docetaxel anhydrous (Taxotere). Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations	Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 26144; PALB2; Simple; p.Lys295_Met296insTer (c.886delA) (p.Met296Terfs); ClinVar=VCV000143979; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
Disease	Ovarian clear cell adenocarcinoma (NCIt: C40078) Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_3509 (ES-2)
Sex of cell	Female
Age at sampling	47Y
Category	Cancer cell line
Publications	PubMed=16382445; DOI=10.1002/gcc.20300 Wang Y.C., Juric D., Francisco B., Yu R.X., Duran G.E., Chen G.K., Chen X., Sikic B.I. Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines. Genes Chromosomes Cancer 45:365-374(2006)
Cell line databases/resources	cancercelllines; CVCL_CZ95
Encyclopedic resources	Wikidata; Q54832438
Gene expression databases	GEO; GSM95429
Polymorphism and mutation databases	Progenetix; CVCL_CZ95
Entry history
Entry creation	13-Jul-2016
Last entry update	05-Oct-2023
Version number	13