Cellosaurus cell line SNU-387/Cas9-hyg (CVCL

Cellosaurus SNU-387/Cas9-hyg (CVCL_C9G8)

Cross-references
Cell line name	SNU-387/Cas9-hyg
Accession	CVCL_C9G8
Resource Identification Initiative	To cite this cell line use: SNU-387/Cas9-hyg (RRID:CVCL_C9G8)
Comments	Population: Korean. Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL537). Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9. Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV). Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys164Ter (c.490A>T); ClinVar=VCV000935480; Zygosity=Homozygous (from parent cell line).
Disease	Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0250 (SNU-387)
Sex of cell	Female
Age at sampling	41Y
Category	Cancer cell line
Cell line collections (Providers)	GeneCopoeia; SL537
Encyclopedic resources	Wikidata; Q123033541
Entry history
Entry creation	05-Oct-2023
Last entry update	19-Dec-2024
Version number	4