Cellosaurus cell line T24/Cas9-hyg (CVCL

Cross-references
Cell line name	T24/Cas9-hyg
Accession	CVCL_C9F3
Resource Identification Initiative	To cite this cell line use: T24/Cas9-hyg (RRID:CVCL_C9F3)
Comments	Population: Caucasian; Swedish. Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL560). Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9. Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations	Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease	Bladder carcinoma (NCIt: C4912)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0554 (T24)
Sex of cell	Female
Age at sampling	82Y
Category	Cancer cell line
Cell line collections (Providers)	GeneCopoeia; SL560
Encyclopedic resources	Wikidata; Q123033600
Entry history
Entry creation	05-Oct-2023
Last entry update	19-Dec-2024
Version number	4