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Cellosaurus CFPAC-1/Cas9-hyg (CVCL_C9DR)

[Text version]
Cell line name CFPAC-1/Cas9-hyg
Accession CVCL_C9DR
Resource Identification Initiative To cite this cell line use: CFPAC-1/Cas9-hyg (RRID:CVCL_C9DR)
Comments Population: Caucasian.
Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL540).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys242Arg (c.724T>C); ClinVar=VCV000449512; Zygosity=Homozygous (from parent cell line).
Disease Cystic fibrosis (NCIt: C2975)
Pancreatic ductal adenocarcinoma (NCIt: C9120)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1119 (CFPAC-1)
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) GeneCopoeia; SL540
Encyclopedic resources Wikidata; Q123030903
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number3