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Cellosaurus BXPC-3/Cas9-hyg (CVCL_C9DP)

[Text version]
Cell line name BXPC-3/Cas9-hyg
Accession CVCL_C9DP
Resource Identification Initiative To cite this cell line use: BXPC-3/Cas9-hyg (RRID:CVCL_C9DP)
Comments Population: Caucasian.
Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL521).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0186 (BxPC-3)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) GeneCopoeia; SL521
Encyclopedic resources Wikidata; Q123030835
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number3