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Cellosaurus HCC70/Cas9-hyg (CVCL_C9CI)

[Text version]
Cell line name HCC70/Cas9-hyg
Accession CVCL_C9CI
Resource Identification Initiative To cite this cell line use: HCC70/Cas9-hyg (RRID:CVCL_C9CI)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL544).
Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1270 (HCC70)
Sex of cell Female
Age at sampling 49Y
Category Cancer cell line
Cell line collections (Providers) GeneCopoeia; SL544
Encyclopedic resources Wikidata; Q123031551
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2