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Cellosaurus HepG2-NTCP1 HBV (CVCL_C9BA)

[Text version]
Cell line name HepG2-NTCP1 HBV
Synonyms HepG2-HBV
Accession CVCL_C9BA
Resource Identification Initiative To cite this cell line use: HepG2-NTCP1 HBV (RRID:CVCL_C9BA)
Comments Population: Caucasian.
Virology: Contains a stably integrated 1.3 mer copy of the Hepatitis B virus (HBV) subtype AYW genome (PubMed=26438841).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 10905; SLC10A1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C9B9 (HepG2-NTCP1)
Children:
CVCL_C9BB (HepG2-NTCP1 HBV Cas9)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=26438841; DOI=10.1073/pnas.1518090112; PMCID=PMC4620859
Tropberger P., Mercier A., Robinson M., Zhong W.-D., Ganem D.E., Holdorf M.
Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.
Proc. Natl. Acad. Sci. U.S.A. 112:E5715-E5724(2015)

PubMed=31801065; DOI=10.1016/j.celrep.2019.10.113
Hyrina A., Jones C., Chen D., Clarkson S., Cochran N., Feucht P., Hoffman G., Lindeman A., Russ C., Sigoillot F., Tsang T., Uehara K., Xie L.-L., Ganem D.E., Holdorf M.
A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production.
Cell Rep. 29:2970-2978.e6(2019)

Cross-references
Encyclopedic resources Wikidata; Q123031639
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number3