Cellosaurus logo
expasy logo

Cellosaurus CLF_PEDS9001_T1 (CVCL_C9B6)

[Text version]
Cell line name CLF_PEDS9001_T1
Synonyms CLF_PEDS9001_T
Accession CVCL_C9B6
Resource Identification Initiative To cite this cell line use: CLF_PEDS9001_T1 (RRID:CVCL_C9B6)
Comments Population: African American.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene fusion; HGNC; HGNC:30036; PLEKHA5 + HGNC; HGNC:11103; SMARCB1; Name(s)=SMARCB1-PLEKHA5; Note=SMARCB1 intron 6 fused to PLEKHA5 intron 10 (PubMed=30860482).
  • Gene deletion; HGNC; HGNC:11103; SMARCB1; Zygosity=Heterozygous (PubMed=30860482).
Disease Kidney medullary carcinoma (NCIt: C7572)
Renal medullary carcinoma (ORDO: Orphanet_319319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=30860482; DOI=10.7554/eLife.44161; PMCID=PMC6436895
Hong A.L., Tseng Y.-Y., Wala J.A., Kim W.-J., Kynnap B.D., Doshi M.B., Kugener G., Sandoval G.J., Howard T.P., Li J., Yang X.-P., Tillgren M., Ghandi M., Sayeed A., Deasy R., Ward A., McSteen B., Labella K.M., Keskula P., Tracy A., Connor C., Clinton C.M., Church A.J., Crompton B.D., Janeway K.A., Van Hare B., Sandak D., Gjoerup O.V., Bandopadhayay P., Clemons P.A., Schreiber S.L., Root D.E., Gokhale P.C., Chi S.N., Mullen E.A., Roberts C.W.M., Kadoch C., Beroukhim R., Ligon K.L., Boehm J.S., Hahn W.C.
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
eLife 8:e44161.1-e44161.32(2019)

Cross-references
Encyclopedic resources Wikidata; Q123030940
Gene expression databases GEO; GSM3687425
Sequence databases dbGAP; phs001800.v1.p1
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3