| Cell line name |
Huh-7.5.1-ACE2 |
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| Accession |
CVCL_C9AS |
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| Resource Identification Initiative |
To cite this cell line use: Huh-7.5.1-ACE2 (RRID:CVCL_C9AS) |
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| Comments |
Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
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| Sequence variations |
- Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
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| Disease |
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_E049 (Huh-7.5.1) |
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| Sex of cell |
Male |
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| Age at sampling |
57Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=35879413; DOI=10.1038/s41588-022-01110-2
Rebendenne A., Roy P., Bonaventure B., Chaves Valadao A.L., Desmarets L.M.B., Arnaud-Arnould M., Rouille Y., Tauziet M., Giovannini D., Touhami J., Lee Y., DeWeirdt P., Hegde M., Urbach S., El Koulali K., de Gracia F.G., McKellar J., Dubuisson J., Wencker M., Belouzard S., Moncorge O., Doench J.G., Goujon C.
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Nat. Genet. 54:1090-1102(2022) |
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| Cross-references |
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| CRISP screens repositories |
BioGRID_ORCS_Cell_line; 1716
|
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| Encyclopedic resources |
Wikidata; Q123032648
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| Entry history |
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| Entry creation | 05-Oct-2023 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 4 |
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