ID   Caco-2-ACE2
AC   CVCL_C9AR
DR   BioGRID_ORCS_Cell_line; 1691
DR   Wikidata; Q123030845
RX   PubMed=35879413;
CC   Group: SARS-CoV-2 research cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 13557; ACE2.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 13557; ACE2.
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
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RX   PubMed=35879413; DOI=10.1038/s41588-022-01110-2;
RA   Rebendenne A., Roy P., Bonaventure B., Chaves Valadao A.L.,
RA   Desmarets L.M.B., Arnaud-Arnould M., Rouille Y., Tauziet M.,
RA   Giovannini D., Touhami J., Lee Y., DeWeirdt P., Hegde M., Urbach S.,
RA   El Koulali K., de Gracia F.G., McKellar J., Dubuisson J., Wencker M.,
RA   Belouzard S., Moncorge O., Doench J.G., Goujon C.;
RT   "Bidirectional genome-wide CRISPR screens reveal host factors
RT   regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.";
RL   Nat. Genet. 54:1090-1102(2022).
//