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Cellosaurus SUM159R (CVCL_C9AN)

[Text version]
Cell line name SUM159R
Synonyms SUM-159PT(R)
Accession CVCL_C9AN
Resource Identification Initiative To cite this cell line use: SUM159R (RRID:CVCL_C9AN)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Selected for resistance to: ChEBI; CHEBI:137113; JQ1.
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Leu (c.3140A>T); ClinVar=VCV000013653; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val157_Arg158insLeu (c.472_473ins3); Zygosity=Unspecified (from parent cell line).
Disease Breast pleomorphic carcinoma (NCIt: C5161)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5423 (SUM159PT)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line

PubMed=26735014; DOI=10.1038/nature16508
Shu S.-K., Lin C.Y., He H.-S.H., Witwicki R.M., Tabassum D.P., Roberts J.M., Janiszewska M., Huh S.J., Liang Y., Ryan J., Doherty E., Mohammed H., Guo H., Stover D.G., Ekram M.B., Brown J., D'Santos C., Krop I.E., Dillon D., McKeown M.R., Ott C., Qi J., Ni M., Rao P.K., Duarte M., Wu S.-Y., Chiang C.-M., Anders L., Young R.A., Winer E., Letai A.G., Barry W.T., Carroll J.S., Long H., Brown M.A., Liu X.-L.S., Meyer C.A., Bradner J.E., Polyak K.
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Nature 529:413-417(2016)

PubMed=32416067; DOI=10.1016/j.molcel.2020.04.027
Shu S.-K., Wu H.-J., Ge J.Y., Zeid R., Harris I.S., Jovanovic B., Murphy K., Wang B.-B., Qiu X.-T., Endress J.E., Reyes J., Lim K., Font-Tello A., Syamala S., Xiao T.-F., Reddy Chilamakuri C.S., Papachristou E.K., D'Santos C., Anand J., Hinohara K., Li W., McDonald T.O., Luoma A., Modiste R.J., Nguyen Q.-D., Michel B., Cejas P., Kadoch C., Jaffe J.D., Wucherpfennig K.W., Qi J., Liu X.-L.S., Long H., Brown M.A., Carroll J.S., Brugge J.S., Bradner J.E., Michor F., Polyak K.
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer.
Mol. Cell 78:1096-1113.e8(2020)

CRISP screens repositories BioGRID_ORCS_Cell_line; 1396
Encyclopedic resources Wikidata; Q123033572
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2