ID   G472NS-Cas9
AC   CVCL_C9A1
DR   BioGRID_ORCS_Cell_line; 1072
DR   Wikidata; Q123031331
RX   PubMed=30995489;
CC   Group: Cancer stem cell line.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C8ZP ! G472
SX   Female
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-09-24; Version: 3
//
RX   PubMed=30995489; DOI=10.1016/j.celrep.2019.03.047;
RA   MacLeod G., Bozek D.A., Rajakulendran N., Monteiro V., Ahmadi M.,
RA   Steinhart Z., Kushida M.M., Yu H., Coutinho F.J., Cavalli F.M.G.,
RA   Restall I.J., Hao X.-G., Hart T., Luchman H.A., Weiss S., Dirks P.B.,
RA   Angers S.;
RT   "Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and
RT   mechanisms of temozolomide sensitivity in glioblastoma stem cells.";
RL   Cell Rep. 27:971-986.e9(2019).
//