ID   C11
AC   CVCL_C8ZJ
DR   BioGRID_ORCS_Cell_line; 1385
DR   Wikidata; Q123030836
RX   PubMed=23804764;
RX   PubMed=32924251;
CC   Population: Caucasian.
CC   Virology: Latently infected with the HIV-1 pseudovirus NL4-3-EGFP where the expression of EGFP is under the control of the HIV-1 LTR. The HIV-1 genome is singly integrated at 16p13.3 (PubMed=23804764).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0065 ! Jurkat
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=23804764; DOI=10.1093/nar/gkt571;
RA   Qu X.-Y., Wang P.-F., Ding D.-L., Li L., Wang H.-B., Ma L., Zhou X.,
RA   Liu S.-H., Lin S.-G., Wang X.-H., Zhang G.-M., Liu S.-J., Liu L.,
RA   Wang J.-H., Zhang F., Lu D.-R., Zhu H.-Z.;
RT   "Zinc-finger-nucleases mediate specific and efficient excision of
RT   HIV-1 proviral DNA from infected and latently infected human T
RT   cells.";
RL   Nucleic Acids Res. 41:7771-7782(2013).
//
RX   PubMed=32924251; DOI=10.15252/embr.201949305;
RA   Yang X.-Y., Wang Y.-N., Lu P.-P., Shen Y.-Z., Zhao X.-Y., Zhu Y.-Q.,
RA   Jiang Z.-T., Yang H., Pan H.-Y., Zhao L., Zhong Y.-C., Wang J.,
RA   Liang Z.-M., Shen X.-T., Lu D.-R., Jiang S.-B., Xu J.-Q., Wu H.,
RA   Lu H.-Z., Jiang G.-C., Zhu H.-Z.;
RT   "PEBP1 suppresses HIV transcription and induces latency by
RT   inactivating MAPK/NF-kappaB signaling.";
RL   EMBO Rep. 21:e49305.1-e49305.13(2020).
//